Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Dose-Dependent Amelioration of Gentamicin-Induced Nephrotoxicity in Adult Swiss Albino Rats by Vitamin B-complex - A Preliminary Study

Shaibu O Bello^1,2 , Aminu Chika¹

¹Department of Pharmacology, College of Health Sciences, Usmanu Danfodiyo University; ²Fertility Unit, Karaye Hospital, Emir Yahaya Road, Sokoto, Nigeria.

For correspondence:- Shaibu Bello Email: bellooricha@yahoo.com Tel:08066024503

Received: 23 June 2008 Accepted: 8 December 2008 Published: 17 April 2009

Citation: Bello SO, Chika A. Dose-Dependent Amelioration of Gentamicin-Induced Nephrotoxicity in Adult Swiss Albino Rats by Vitamin B-complex - A Preliminary Study. Trop J Pharm Res 2009; 8(2):111-116 doi: 10.4314/tjpr.v8i2.3

© 2009 The authors.
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Abstract

Purpose: To evaluate the effect of vitamin B-complex on the nephrotoxicity of gentamicin in an established rat model.

Methods: Adult Swiss albino rats weighing 170±20g were divided into 4 groups of 4 rats each. Each group was given one of the following: placebo injection (Control), 80mg/kg of gentamicin sulphate alone or with 1.5ml/kg/3ml/kg body weight of vitamin B-complex (intramuscular) containing 10mg thiamine, 1.5mg riboflavin and 1.0mg pyridoxal-6-phosphate per ml.

Results: In the Swiss albino rats, daily intramuscular 80mg/kg gentamicin sulphate significantly (p<0.05) and consistently produced biochemical signs of nephrotoxicity after 5 days. Also, 1.5 ml/kg of B-complex significantly (p<0.05) ameliorated the rate and extent of increase in serum urea and creatine while 3ml/kg of the same drug completely prevented the increase in serum urea and creatine in this model.

Conclusion: Vitamin B-complex dose-dependently ameliorated gentamicin-induced nephrotoxicity in adult Swiss albino rats when given intramuscularly. This finding may have important clinical utility.

Keywords: Gentamicin, B-complex, Swiss albino rats, Nephrotoxicity, Serum urea and creatine